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Biological mechanisms have also been associated with poor
2019-06-29
Biological mechanisms have also been associated with poor cardiovascular outcomes in ICD patients with depression, such as alteration of cardiac autonomic tone, activation of the sympathetic nervous system, enhanced activity of the hypothalamic-pituitary-adrenal axis, and elevated inflammatory and p
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br Remote technologies The platforms available
2019-06-29
Remote technologies The platforms available for remote monitoring of ICDs differ. Wand-based (“inductive”) systems require patient-driven downloads relayed via telephone connections to tracking facilities [4,5]. These are becoming obsolete. This is because they demand coordination with a device c
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Pimasertib The renin angiotensin system plays a
2019-06-29
The renin-angiotensin system plays a crucial role in atrial fibrosis, which is a key pathological consequence of AF. Genes encoding 3 molecules related to the renin-angiotensin system, including angiotensin-converting enzyme (ACE), angiotensinogen, and angiotensin type 1 receptor (AT1R), are associa
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Tie2 kinase inhibitor of br Materials and methods br
2019-06-29
Materials and methods Results Discussion Although EMT can be induced by different factors under exogenous stimuli, it is intriguing to consider whether these EMT inducers are redundant because of their mechanistic similarity in EMT induction. The interplay and underlying mechanism between E
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Both breast cancer and MM cause
2019-06-29
Both breast cancer and MM cause osteolytic lesions, inhibiting osteoblast differentiation and thereby tipping the balance in favour of osteoclastic activity. In contrast, prostate cancer predominantly causes osteoblastic bone disease. Interestingly, increased marrow adiposity has been associated wit
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The benign exostoses in TRPS have a recognized malignant pot
2019-06-29
The benign exostoses in TRPS have a recognized malignant potential which have been shown to develop into chondrosarcomas [4,13]. Both our index case and his mother demonstrated de novo high grade osteosarcoma. To our knowledge, this occurrence has not been described anywhere within the literature.
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Validation study findings showed that
2019-06-29
Validation study findings showed that knowledge (KR20=0.58) had moderate internal consistency. Even though this was fairly acceptable, the knowledge domain was considered a good test as KR20 tends to result in more conservative estimates than Cronbach’s alpha [28]. Enhancing the reliability of a que
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br Discussion We describe an additional diagnosis to
2019-06-29
Discussion We describe an additional diagnosis to consider when BVT is identified. One of the proposed mechanisms of BVT include elevated intracellular calcium, causing delay after depolarization in anatomically separate parts of the conducting system. Baher et al. [1] proposed that two separate
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In Tara Mangal and colleagues report the
2019-06-29
In , Tara Mangal and colleagues report the results of their case-control study into the persistence of poliomyelitis in Nigeria, which identified low vaccine efficacy, poor vaccine coverage, suboptimum EMD-1214063 immunity, rejection and refusal of vaccine, and lack of awareness as issues responsib
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We would like to also clarify that we
2019-06-29
We would like to also clarify that we do not underestimate the CIs in our study through the assumption that GDP was observed independently for every child in the survey. The multilevel design and clustering of standard errors at the survey level accounts for the fact that GDP is not observed indepen
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When the subject of climate change is raised
2019-06-29
When the subject of climate change is raised, people tend to think of extreme heat events, droughts, violent storms, rising sea levels, and floods. Today, we certainly live in an era of severe weather events, which will intensify if human-driven climate change continues unabated. Such events are kno
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By showing the great variability in surgical outcomes across
2019-06-29
By showing the great variability in surgical outcomes across LMICs, Uribe-Leitz and colleagues have shared with the world instructive knowledge that aids our ongoing advocacy efforts to promote quality in surgical care in resource-limited settings. Ultimately, for destitute sick and injured patients
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Successful and safe catheter ablation is facilitated by
2019-06-29
Successful and safe catheter ablation is facilitated by an appreciation for anatomical particularities and surgical details. Morphological analysis of clinically documented VT is also important. In these patients, VT usually shows a left bundle branch block-like QRS morphology and inferior frontal p
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br Discussion There are many
2019-06-29
Discussion There are many reports on the effectiveness of pacing therapy for hypertrophic obstructive cardiomyopathy. Fananapazir et al. reported that long-term right ventricular apical pacing improved both the left ventricular outflow tract gradient and subjective symptoms [3]. Maron et al. repo
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Thalidomide molecular br Conflict of interest br Acknowledgm
2019-06-28
Conflict of interest Acknowledgments Introduction Electroanatomical mapping is useful for locating a possible reentrant circuit, but it has limitations in terms of analyzing the functional property of the circuit [1,2]. Entrainment mapping using the postpacing interval (PPI) and the activat
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