• The study reported here had

  2021-04-15

  

  The study reported here had the primary goal to compare the methylation of HPV late genes with methylation of the DAPK promoter, and with histological or cytological diagnoses among high-risk patients that were referred to a colposcopy clinic based on abnormal cervical cytology. Based on the literat

• Although PGD was initially considered to elicit its biologic

  2021-04-15

  

  Although PGD was initially considered to elicit its biological actions through a classical PGD receptor (DP1), later findings suggested that several PGD-mediated actions of eosinophils arise via DP2,, which is also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)

• br Acknowledgments The authors thank Elisabete Lepera and Ro

  2021-04-15

  

  Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction

• br The amygdala complex The amygdala complex is composed of

  2021-04-15

  

  The amygdala complex The amygdala complex is composed of distinct nuclei and subdivisions including the lateral (LA), basolateral (BL), and basomedial (BM) amygdala; the medial (Imp), lateral paracapsular (lpc), and main intercalated cell cluster (IN); and the lateral and medialcentral amygdala (

• PF-477736 Another question concerns the mechanism of PC redu

  2021-04-15

  

  Another question concerns the mechanism of PC reduction during the phosphate starvation response. There are at least three main mechanisms of PC depletion: suppression of PC synthesis due to substrate exhaustion, downregulation of PC synthase expression by suppression of gene transcription or intens

• (±)-J 113397 The strong adsorption of amines to the sta

  2021-04-15

  

  The strong adsorption of amines to the stationary phase of gas chromatography (GC) columns causes issues such as tailing, ghosting and low reproducibility [12], [13]. A common practice to overcome this problem is the chemical derivatisation of amines prior to GC analysis [14]. Comprehensive reviews

• In this clinical context measures

  2021-04-15

  

  In this clinical context, measures of cell-mediated immune response to CMV have been evaluated. The QuantiFERON-CMV assay (QFN-CMV; Qiagen, Germany) which measures predominantly CD8+ T-cell responses to CMV by an in-tube IFN-gamma release technique is commercially available in some regions.1, 2 Cons

• br Experimental Procedures br Acknowledgments br Bisphenol A

  2021-04-15

  

  Experimental Procedures Acknowledgments Bisphenol A (BPA) has been recognized as one of the most potent endocrine disruptors, functioning even at very low doses. Although it is anticipated that enolase receptor (ER) would mediate these effects of low-dose BPA, studies revealed that BPA bound

• Lavallee et al reported that PREG could

  2021-04-15

  

  Lavallee et al. [30] reported that PREG could be esterified by lecithin:cholesterol acyltransferase (LCAT). LCAT uses cholesterol and phosphatidyl choline present in the newly formed high-density lipoprotein (HDL) as substrates and convert them into cholesteryl esters and lysophosphatidyl choline. T

• The indigenous populations living at high

  2021-04-15

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human bwx to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary and haematological a

• br Conclusions br Declaration of interest

  2021-04-15

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• Moreover considering that several polyphenols and flavonoids

  2021-04-15

  

  Moreover, considering that Trehalose several polyphenols and flavonoids (i.e. chalcones, flavanones, resveratrol derivatives, ellagic acid) are reported to inhibit tyrosinase and elastase (Pillaiyar et al., 2017; Xing et al., 2016; Wittenauer et al., 2015), the relations between enzyme inhibitory ac

• The discoidin domain receptors DDR and

  2021-04-15

  

  The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by different types of collagen (Shrivastava et al., 1997, Vogel et al., 1997). Both receptors interact with a number of fibrillar collagens, and DDR1, but not DDR2, is also activated by the network-formin

• Given its high frequency it

  2021-04-15

  

  Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant KB SRC 4 to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been proved

• Most of the data indicating that the

  2021-04-15

  

  Most of the data indicating that the six-ankyrin repeat domain-containing Asb genes drive compartment expansion come from zebrafish and concern Asb11. However, there is evidence to suggest that these data can be expanded to the entire vertebrate phylum and to all six-ankyrin repeat domain-containing

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