• The physiologic conditions and signaling

  2023-05-29

  

  The physiologic conditions and signaling mechanisms that regulate apelin secretion and APLNR expression in malignant tissues appear to be multifactorial. Previous studies have shown that hyperplastic and neoplastic cholangiocytes secrete a variety of hormones, peptides, and growth factors that help

• br Antifungal resistance what is in

  2023-05-29

  

  Antifungal resistance, what is in a name? Antifungal resistance is an emerging and hot topic in the field of medical mycology. Microbiological resistance is identified by determining minimal inhibitory concentrations (MICs) in vitro for a given antifungal and interpreting this value according to

• Brefeldin A australia The first and the best characterized m

  2023-05-29

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic Brefeldin A australia receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional mo

• br Disclosure br Acknowledgments br Introduction Deeper unde

  2023-05-29

  

  Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small Suramin hexasodium salt that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations

• Cells have developed strategies aiming to

  2023-05-29

  

  Cells have developed strategies aiming to enhance both the efficiency of proteins with chaperone activity as well as their overall antioxidant capacity to maintain proteostasis under oxidative stress conditions (Miyata et al., 2012). For instance, 2-Cys peroxiredoxin is an abundantly expressed, anti

• 2858 br Materials and methods br

  2023-05-29

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P 2858 concentrations significantly increased in chicks after 1 h of refeeding (958 ± 245% of 24 h-fasting gro

• Glucose permeability studies demonstrated a high glucose flu

  2023-05-29

  

  Glucose permeability studies demonstrated a high glucose flux through the SF films used in the present work. Recent diffusion studies, including small molecular drugs and oxygen permeation through SF membranes [32], further support the quality of SF and its possible application as a material for bio

• br The role of apelin

  2023-05-29

  

  The role of apelin in hypertension diseases The role of apelin and its receptor APJ in cardiovascular diseases has been described in numerous studies (Table 2) [36,37]. It has been revealed that exogenous apelin may lower blood pressure. Tatemoto et al. [6] have discovered that different forms of

• Recently different kinds of A aggregation inhibitors have be

  2023-05-26

  

  Recently, different kinds of Aβ aggregation inhibitors have been reported, including small molecules [8], peptides [9], and nanoparticles (NPs) [10]. The working mechanisms of the inhibitors are mostly to bind or adsorb Aβ molecules and to affect the conformational changes followed by blocking the a

• br Materials and methods br Results br Discussion

  2023-05-26

  

  Materials and methods Results Discussion Endophilin A1 is a membrane-binding protein that is mainly distributed in the central nervous system (Giachino et al., 1997), localizes in the dendritic shafts and spines of mature neurons (Yang et al., 2015), and relates to the function and morpholo

• A unique finding in this study is

  2023-05-26

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic ligand gated for substrate, can regulate CREB phosphoryation in the context of Alzheimer

• MB05032 br Conclusions and clinical relevance Astrogliosis a

  2023-05-26

  

  Conclusions and clinical relevance Astrogliosis and an increase in ADK is a pathologcial hallmark of epilepsy. The consequence of increased ADK in the epileptic MB05032 is a decrease in the ambient adenosine tone and A1R activity. As a result, systemic administration of A1R agonists or ADK inhib

• Sperm total motility and hyperactivated motility

  2023-05-26

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent papain polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrating low motility contained low le

• br STAR Methods br Author Contributions br

  2023-05-26

  

  STAR★Methods Author Contributions Acknowledgments We thank Antony M. Dean for initial discussions and encouragement concerning ancestral sequence reconstruction. We also thank Natalie K. Goto for constructive criticism concerning the manuscript, Steven M. Sine for providing herpes simplex v

• Princen Panier specifically address the issue of ACE using t

  2023-05-26

  

  Princen, 2012, Panier, 2013 specifically address the issue of ACE using the commercial database AMADEUS. However, both studies focus only on corporate leverage and the ACE in Belgium. Due to the lack of a counterfactual, these authors consider firms in other European countries, e.g., France, as a co

15548 records 280/1037 page Previous Next First page 上5页 276277278279280 下5页 Last page