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Keeping SCs out of the active cell cycle
2018-10-20
Keeping SCs out of the active purchase GW5074 phase and minimizing the risk of DNA damage may be especially important in aging and has led to a SC hypothesis of aging (Sharpless and DePinho, 2007; Beausejour and Campisi, 2006). We succeeded in transiently inhibiting DREAM expression 24h after siRNA
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The following are the supplementary data related to this
2018-10-20
The following are the supplementary data related to this article. Acknowledgments The authors wish to thank Dr. K. Inoue for the S100β/GFP-TG rats, Dr. A.F. Parlow and the NIDDK for the mm concentration against pituitary hormones, Dr. S. Tanaka at Shizuoka University for the antibody against hum
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Main Text These are exciting times for stem cell
2018-10-20
Main Text These are exciting times for stem cell research and its application to human health. Unprecedented opportunities now exist to harness the power of stem l-ascorbic acid to understand and treat disease. We continue to learn more about the potential of stem cells of many different types to
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br Results br Discussion Enriched CMs are
2018-10-20
Results Discussion Enriched CMs are highly desirable for research and translational applications such as drug discovery and cell therapy, as well as mechanistic characterization of inherited cardiac diseases with iPSC-CMs; for example, gene-expression profiling between patient- and unaffected
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notch signaling br Acknowledgments br Introduction The intes
2018-10-20
Acknowledgments Introduction The intestinal epithelium provides a paradigmatic model for understanding stem cell organization and dynamics in highly proliferative tissues. The past decade has seen numerous breakthroughs in our understanding of intestinal stem cells (ISCs). Prior to 2007, the e
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br Results br Discussion Prior reports of differentiating
2018-10-20
Results Discussion Prior reports of differentiating hPSCs to endothelial cells required the addition of expensive growth factors and/or undefined serum to direct endothelial development, and these methods generated heterogeneous cell mixtures typically containing less than 10% endothelial cell
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Here we set out to evaluate the roles of transcriptional
2018-10-20
Here we set out to evaluate the roles of transcriptional regulators associated with EMT in iPSC reprogramming. We were intrigued by data from published reports that EMT factors (including SNAI1) increased during the early stages of reprogramming (Mikkelsen et al., 2008; Samavarchi-Tehrani et al., 20
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Previously our group has isolated human embryonic stem
2018-10-20
Previously, our group has isolated human embryonic stem Erismodegib manufacturer (ESCs) whose pluripotent state is maintained in vitro by exogenous growth factor signaling, particularly fibroblast growth factor (FGF), insulin or insulin-like growth factor, and transforming growth factor (Bendall et
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Mass spectrometry MS based proteomics is a powerful approach
2018-10-20
Mass spectrometry (MS)-based proteomics is a powerful approach for the comparative analysis of protein Retigabine dihydrochloride between cell populations. Global approaches have been used to define the MSC proteome (Delorme et al., 2008; Mareddy et al., 2009; Mindaye et al., 2013a, 2013b) and to tr
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br Conclusions All approaches described in
2018-10-20
Conclusions All approaches described in this review for in vivo or in vitro SSC maturation yielded functional sperm and offspring in at least one animal model (Table 1) (Shinohara et al., 2002; Wu et al., 2012; Sato et al., 2011; Nakai et al., 2010; Liu et al., 2013; Kaneko et al., 2013; Ogawa et
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It should be noted that the apparently inconsistent results
2018-10-20
It should be noted that the apparently inconsistent results regarding the CD146 status of human ASCs, which were obtained in several studies (Bourin et al., 2013) could at least in part be explained with transitory cells of different sizes, which contain different CD146 protein levels, and with matu
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Thus transplanted iNSCs inhibit NF
2018-10-20
Thus, transplanted iNSCs inhibit NF-κB activation in the buy Tanespimycin post-CHI. In brief, these results indicate that iNSC grafts may act through NF-κB signaling to regulate the immune response. Here are the details: 1) the levels of IL-1β and TNF-α secreted by immune cells are down-regulated a
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br Results br Discussion Directed differentiation protocols
2018-10-20
Results Discussion Directed differentiation protocols have been employed to efficiently generate cardiomyocytes from both mouse and human ESCs (Kattman et al., 2011). However, it has remained a challenge to efficiently generate CCS cells using currently established protocols. In this study, we
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A variety of studies have compared the expression profiles
2018-10-20
A variety of studies have compared the expression profiles, pluripotentiality, and genetic and epigenetic stability of hESC and iPSC including lines generated using different strategies, distinct parental somatic cell types, or reprogramming methods (Bock et al., 2011; International Stem Cell Initia
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The pituitary gland is considered the master
2018-10-20
The pituitary gland is considered the master gland of hormone function. Hypopituitarism is a disease condition with insufficient or absent function of the pituitary gland. Pituitary tumors are the most common cause but many other triggers can induce pituitary dysfunction including inborn genetic def
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