• Previous studies have used acute irradiation induced

  2018-11-02

  

  Previous studies have used acute irradiation-induced injury models to provide mechanistic insight into the regeneration process, revealing that actively proliferating IESC (active IESC) and slowly proliferating IESC (quiescent IESC) populations occur within the lower regions of the crypt (Barker et 

• dihydrofolate reductase Multiple mechanisms have been descri

  2018-11-02

  

  Multiple mechanisms have been described that sensitize ESCs to DNA damage-induced apoptosis. First, human ESCs possess unique ROCK-dependent mechanisms in singularized dihydrofolate reductase that lead to a myosin-mediated form of cell blebbing, which rapidly triggers apoptosis upon cell detachment

• Introduction Stem cells including neural stem cells NSCs res

  2018-11-02

  

  Introduction Stem cells, including neural stem cells (NSCs), reside in specialized compartments that contribute to their maintenance. In the embryonic and adult mammalian brains, signals emanating from cells in the niche or the cerebrospinal fluid promote NSC self-renewal and proliferation (Lehtine

• Our study made use of single cell transcriptional

  2018-11-02

  

  Our study made use of single-cell transcriptional profiling to define the heterogeneity of hormone-producing transferases derived from hPSCs. The technology is a powerful tool that allowed us to determine the percentage of various hormone-producing cells and shifts in this distribution upon treatmen

• One of the versions of this EOS is shown in

  2018-11-02

  

  One of the versions of this EOS is shown in Fig. 1. The cathode has bracket-shaped cross-section. Nanocarbon emitting coating is deposited onto its inner surface. The anode in the form of two thin tungsten wires is placed inside the cathode box. Full axial length of the system may substantially exce

• A test was also performed on

  2018-11-02

  

  A test was also performed on the time-step sensitivity of the obtained results. The solutions compared were obtained with the steps of 0.005, 0.010 and 0.020s. As a result, it was found that the solution varied only slightly with decreasing time steps in the specified range; because of this, the mai

• The quality of each paper

  2018-11-02

  

  The quality of each paper was depicted by a score summarising the metrics to provide an overall impression of the quality of the available evidence. A weighting system was employed whereby the score for each metric was divided by the maximum possible value so that each metric had the same weighting

• br Materials and methods br Results br Discussion

  2018-11-01

  

  Materials and methods Results Discussion The results support our hypothesis that the pro/anti-inflammatory complement components can predict PSG sleep measures. The associations between objective sleep measures and inflammatory complement components are similar to those between objective sl

• Parad jicamente puede establecers http www apexbt com media

  2018-11-01

  

  Paradójicamente puede establecerse un paralelismo: el fetichismo de la mercancía ha transmutado en un fetichismo por lo que hoy se entiende por la ciencia económica pura, que ha servido para justificar la lógica de explotación que subyace ep4 receptor la guerra de los codiciosos en su versión del si

• br Methods br Funding br Ethical

  2018-11-01

  

  Methods Funding Ethical clearance Results We included 89 children as described in Fig. 2, with 281 PBs, comprising 189 pairs of successive PBs (average of 3.15 biopsies per patient). Characterization features are summarized in Table 2 and details provided in Supplementary Tables 1 and 2.

• Given the present data we are not able to explain

  2018-11-01

  

  Given the present data, we are not able to explain why the left auditory Ezetimibe was overactivated during 80-Hz ASSR stimulation. However, the left and right transverse temporal gyri and left planum temporale have some differential cytoarchitectonic features (Seldon, 1981; Hutsler and Gazzaniga,

• br Conflicts of Interest br Author

  2018-11-01

  

  Conflicts of Interest Author Contributions X.Y. and X.W. designed and performed experiments. J.L.L. and X.D.H. performed in vivo knock-in experiments. L.Y. S., X.W.S. and W.Q.Y. assisted with cloning and animal experiments. X.Y.S. and X.W. assisted with animal experiments. H.Y. and P.Y.H. supe

• Since persistent telomeric DNA damage is a feature

  2018-11-01

  

  Since persistent telomeric DNA damage is a feature of replicative, stress- and oncogene-induced senescence, it has been suggested that unrepaired telomeres provide a source of persistent DDR signaling which is important to the establishment of senescence (Fumagalli et al., 2012). However, damage at

• We have long been searching for chemicals that could

  2018-11-01

  

  We have long been searching for chemicals that could prevent such cell death in vivo. For this purpose, we have hypothesized that such chemicals would maintain cellular ATP levels under these pathological conditions. In order to address this hypothesis, we developed KUSs as specific inhibitors of th

• Value of the data br Data experimental design materials and

  2018-11-01

  

  Value of the data Data, experimental design, materials and methods Acknowledgments This work was financially supported by the grant sponsors: Shenzhen Municipal Committee of Science and Technology Innovation (Grant number: JC201105190969A) and the National Public Sector (AQSIQ) Special Funds

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