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br Predictors of benefit from bisphosphonates
2019-05-09
Predictors of benefit from bisphosphonates Randomized control studies of adjuvant BP therapy in early breast cancer show benefit related to “low estrogen states” [1,2,5,6]. Unfortunately, thus far, only one study has assessed systemic estrogen levels to substantiate these results. This is clearly
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Regarding the treatment of HLH with HLH
2019-05-08
Regarding the treatment of HLH with HLH-1994, the estimated 3-year probability of survival overall was 55%. According to a previous comprehensive review study, ferritin level may provide a prognostic marker, and regular ferritin measurements may be useful in predicting outcomes in HLH patients. Our
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Limited data exist concerning the long
2019-05-08
Limited data exist concerning the long-term incidence and prognosis of GW5074 cost failure after myocardial infarction, particularly in the era of coronary revascularization. New-onset heart failure significantly increases the mortality risk among these patients [23]. Current ICD trials have shown
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clemastine fumarate Performing an ajmaline test in children
2019-05-08
Performing an ajmaline test in children is problematic for 2 reasons. First, the test is apparently less sensitive in children than in adults. In fact, in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed duri
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Esto es visible no s lo en las notas necrol
2019-05-08
Esto es visible no sólo en las notas necrológicas, sino también en los discursos que homenajean beta lactamase inhibitor alguien en ocasión de su retiro o jubilación. En ellos encontramos rasgos comunes con las notas necrológicas, sobre todo en la idea de una herencia que deja el que se va, y que co
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Demand for kidney transplantation for ESKD has
2019-05-08
Demand for kidney transplantation for ESKD has already outstripped the supply of donated Sunitinib Malate from living donors, notwithstanding the inadequate donor pool. End-of-life donation can potentially expand the donor pool but is less common. For example, in India, among the 12 294 renal trans
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Two other groups subsequently published further data on iPSC
2019-05-08
Two other groups subsequently published further data on iPSCs models of ARVC that have improved our understanding of this disease. Kim et al. developed iPSC models using episomal methods from 2 ARVC patients, as well as with PKP2 mutations . Detailed electrophysiological characterization of mutant a
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br Case report A year old Japanese woman gravida was
2019-05-08
Case report A 34-year-old Japanese woman, gravida 0, was admitted to the hospital for preterm labor at 24 weeks\' gestation. She was administered intravenous magnesium sulfate therapy for drug-induced liver injury caused by intravenous ritodrine hydrochloride. Five days later, the fetal heart rat
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The Cl HCO anion exchanger
2019-05-07
The Cl−/HCO3− anion exchanger 2 (AE2) is found on cholangiocytes and regulates intracellular pH homeostasis and stimulates bicarbonate secretion. Previous reports have revealed that PBC patients show decreased biliary AE2 expression, and researchers hypothesized that this decrease in AE2 LY 2157299
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Lymphocytic infiltrates in thyroid cancer may
2019-05-07
Lymphocytic infiltrates in thyroid cancer may suggest a background of chronic lymphocytic thyroiditis. Thyroiditis is characterized by a cellular immune response with dense lymphocytic infiltration of the thyroid gland, as well as by a humoral immune response leading to the production of autoantibod
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First Speakman and colleagues do not mention
2019-05-07
First, Speakman and colleagues do not mention the developments in the 2000s, when notable EU attention was given to global health. In 2010, there was a high-level conference and the launch of a European Commission Communication, which stated that the EU\'s commitment to global health should mainly f
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Others have observed the marked
2019-05-07
Others have observed the marked differences in clinicopathological characteristics between breast cancer subtypes by IHC study. However, they reported that triple negative and HER2 patients are at high risk of recurrences after adjusting for age, stage and histological grade. Our data support this o
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The authors would like to thank Ms Fang Ju Sun
2019-05-07
The authors would like to thank Ms. Fang-Ju Sun for her help with statistical analysis. This study was supported by a research grant from Mackay Memorial Hospital (MMH10466). Introduction Cancer of the YO-01027 (CC) is the second most common cancer affecting women worldwide, and about 86% of CC
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Introduction Multiple myeloma MM is the
2019-05-07
Introduction Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with 80–90% of patients developing bone lesions during their disease course [1]. Myeloma bone lesions are purely osteolytic and are associated with severe and debilitating bone pain, pathologic fractures, hyperca
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Heat shock facilitates the folding of various proteins as
2019-05-07
Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is
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