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Many countries in all over
2021-03-13

Many countries in all over the world generate a large amount of RHA from uncontrolled and controlled burning. RHA is a pozzolanic material due to this high percentage of SiO2 in RHA. Rice husk ash, as a mineral additive, is produced by burning rice husks, which are obtained in the rice milling indus
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br Methods br Results br Discussion I R induces
2021-03-13

Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide Metformin dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase and NOS
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The Liver X Receptor and
2021-03-13

The Liver X Receptor-α and -β (LXRs, NR1H3 and NR1H2, respectively) are members of the nuclear receptor superfamily that play a central role in controlling cholesterol homeostasis [9], [10]. In macrophages, LXRs can decrease the cellular sterol burden by inducing expression of the cholesterol efflux
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In contrast a single instillation
2021-03-13

In contrast, a single instillation of BLM results in a progression of inflammatory events that culminates in marked remodeling of the lung interstitium. This process takes 2–3 weeks, with the fibrotic lesions becoming most pronounced within the first month [9]. Consequently, the BLM model offers the
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br Lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia
2021-03-13

Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin
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DSBs can be repaired by two major
2021-03-13

DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012). c-NHEJ comprises two sub-pathways, a resection-independent process and a resection-dependent process, and can rejoin break ends with little or no sequen
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We recently reported that the
2021-03-13

We recently reported that the information about the electronic density obtained from a QTAIM analysis is useful to describe the molecular interactions that stabilize and destabilize the different complexes L-R [13], [14], [15]. Specifically in our previous work reported for DHFR inhibitors, the QTAI
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DDR is characterized by an N terminal discoidin domain
2021-03-13

DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of expression level in cancer tissues and biological functions in normal and cancer cell conditions, but char
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Several RNA BPs like the ELAV protein family member
2021-03-12

Several RNA-BPs, like the ELAV protein family member HuR, tristetraprolin (TTP) or the KH-type splicing regulatory protein (KSRP) have been shown to interact with these AREs and thereby lead to stabilization or destabilization of the mRNA [5]. Control of nucleocytoplasmic mRNA export is also very i
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RQ What are the different factors that influence the
2021-03-12

RQ2: What are the different factors that influence the decision to choose among different component origins? In total eleven factors grouped into three high-level themes that influence the decision to choose a component origin were identified. The project metrics factors are: time, cost, effort and
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Sensory gating describes a filter mechanism protecting the
2021-03-12

‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits Clindamycin HCl to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003). Au
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CJ-42794 The mechanisms by which coregulators control the ac
2021-03-12

The mechanisms by which coregulators control the actions of estrogen receptors are still a topic of ongoing research. From studies in cancer cells, we have learned that a large group of coregulators have specific structural motifs that than affect their contact with ER ligand-binding domains (Heery,
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br Acknowledgment S A was supported by V Plan Propio
2021-03-12

Acknowledgment S.A was supported by V Plan Propio US-AccesoUSE-14793-G. Introduction Neutrophils are innate immune Phleomycin of primary importance for protecting against infections by microorganisms [1,2] through various antimicrobial abilities, including microorganism phagocytosis and anti
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br Acknowledgments The research in this study was supported
2021-03-12

Acknowledgments The research in this study was supported by grants from CMHS, UAE University and Qatar University. The authors gratefully acknowledge Dr. R Lukas (Barrow Neurological Institute, Phoenix, AZ, USA) for SH-EP1 Gefitinib hydrochloride stably expressing the human α7 nACh and human α4β
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In summary the metabolism of
2021-03-12

In summary, the metabolism of GEF in HLM and MLM was extensively studied using a LC–MS-based metabolomic approach. This study identified a total of 34 metabolites and adducts related to GEF (Fig. 10) and identified three new potential reactive metabolites, including two aldehydes and one iminium. P
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