• ER redox imbalance leads to

  2021-04-02

  

  ER redox imbalance leads to the accumulation of misfolded proteins, which might trigger the unfolded protein response (UPR) [17]. In the initiation of UPR, GRP78 preferentially binds to unfolded proteins, shifting the binding equilibrium away from IRE-1, PERK, and ATF-6, the initiators of UPR [18].

• Although the amino acid sequences of CUL A and

  2021-04-02

  

  Although the amino Gemcitabine sequences of CUL4A and CUL4B share 82% identity, the existing studies have shown that these two proteins do not have significant functional redundancy. Elevated expression of CUL4A has been observed in a variety of cancer cells, such as breast cancer, ovarian cancer,

• br Methods br Results br

  2021-04-02

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific (S)-(-)-Propranolol hydrochloride organs (Donadio et al., 2005, Donadio et al.,

• The inhibition of DNMT using

  2021-04-02

  

  The inhibition of DNMT1 using 5-AZA-dC or DNMT1 siRNA increased TIMP2 protein and mRNA expression, suggesting that TIMP2 expression is down-regulated by DNA methylation in the HDFs. In addition, 5-AZA-dC treatment led to a dose-dependent decrease of DNMT1 protein expression. 5-AZA-dC is a cytosine a

• Oral antipsychotics are substrates of CYP enzymes

  2021-04-02

  

  Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult

• Several evidences showed that seizures increase

  2021-04-02

  

  Several evidences showed that seizures increase brain extracellular glutamate, which binds to N-methyl-d-aspartate (NMDA) receptor, then up-regulated cyclooxygenase-2 (COX-2) expression in brain capillaries to increase BBB P-gp expression [11,13,29,30]. A recent study demonstrated a different signal

• br Experimental section br Results br

  2021-04-02

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised [Ala92]-p16 (84-103) did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a p

• At the same time that the CPA education requirements have

  2021-04-02

  

  At the same time that the CPA education requirements have been increasing, the composition of the post-secondary student population has experienced a substantial increase in the number and relative proportion of students who delay college or university matriculation. These students tend to exhibit a

• Targeting the MAPK pathway has attracted

  2021-04-01

  

  Targeting the MAPK pathway has attracted significant interest in cancer therapy. Efforts directly targeting RAS protein are believed to be very challenging in spite of the promise shown by a few RAS inhibitors in the early development stage. Clinical benefits achieved by BRAF and MEK inhibitors have

• It is well known that

  2021-04-01

  

  It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o

• Enzyme mimics belong to a type of rising

  2021-04-01

  

  Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a

• It has been observed in

  2021-04-01

  

  It has been observed in our results that patients carrying risk allele “a” are at the greater risk of developing psoriasis. Same results have been presented by Coto-Segura et al., 2011, in a study conducted on Spanish population where they reported association of VNTR polymorphism among the patients

• In contrast a single instillation

  2021-04-01

  

  In contrast, a single instillation of BLM results in a progression of inflammatory events that culminates in marked remodeling of the lung interstitium. This process takes 2–3 weeks, with the fibrotic lesions becoming most pronounced within the first month [9]. Consequently, the BLM model offers the

• Oysters belong to the second

  2021-04-01

  

  Oysters belong to the second largest animal phylum Mollusca, and they are globally distributed aquaculture animals (Wang et al., 2018). A number of studies have demonstrated that oysters have evolved an integrated and complex innate immune system to recognize and eliminate various invaders. An array

• tmn br Development of the double strand break repair

  2021-04-01

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using tmn in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas H. Morgan [22]

15646 records 647/1044 page Previous Next First page 上5页 646647648649650 下5页 Last page