• Resolving the molecular details of

  2021-12-08

  

  Resolving the molecular details of (glyco)proteome variation in different tissues and organs of the human body is critical for the understanding of human biology and disease [59]. Glycoproteomic analysis of disease-related tissues and cells has provided valuable information to identify promising tar

• Deregulation of HH signaling pathway

  2021-12-08

  

  Deregulation of HH signaling pathway in epidermal keratinocytes is a primary event leading to the formation of BCC (see above). Overexpression of SHH in HaCaT keratinocytes grown in organotypic cultures induces a basal cell phenotype and increases invasiveness. This behavior is linked to increased E

• Therefore as it stands presenilin has a secretase independen

  2021-12-08

  

  Therefore as it stands, presenilin has a γ-secretase-independent role in regulating protein trafficking, proteolysis and degradation, however given that inhibition of γ-secretase activity can have a negative effect on protein trafficking [69], [98], we cannot exclude the possibility that some of th

• Zn is the second most abundant trace metal

  2021-12-08

  

  Zn2+ is the second most abundant trace metal in many cells and neurons in the brain. It regulates cellular functions such as gene expression, epigenetic enzymatic activity, protein structural stability, and neuronal plasticity. Zn2+ is particularly abundant in the cortex and limbic system, including

• br Materials and methods br Results and discussion br

  2021-12-08

  

  Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm

• Methods br Results br Discussion SV exocytosis from excitato

  2021-12-07

  

  Methods Results Discussion SV exocytosis from excitatory boutons is more sensitive to inhibition by isoflurane than exocytosis from inhibitory boutons,4, 31 but the mechanism(s) of this synaptic selectivity is unknown. Although P/Q-type VGCCs contributed quantitatively more to SV exocytosis t

• br cAMP cGMP effector systems in human platelets PKA

  2021-12-07

  

  cAMP/cGMP effector systems in human platelets (PKA, PKG, PDEs) In eukaryotic cells, the effects of intracellular cAMP are mediated by two types of cAMP-dependent protein kinases (PKA type I and II) and cAMP-regulated guanine nucleotide exchange factors (EPAC/cAMP-GEF) which activate the RAS GTPas

• Further SAR was explored with

  2021-12-07

  

  Further SAR was explored with the imidazole series to achieve better enzyme inhibition activity (). In comparison to published earlier, replacing the amide with sulfonamide and reverse sulfonamide maintained the GSNOR inhibitory activity. It is clear that exchanging the phenyl ring (, and ) by thien

• Because of its excellent GPR potency good hERG selectivity

  2021-12-07

  

  Because of its excellent GPR119 potency, good hERG selectivity and favorable rat t, β-Funaltrexamine hydrochloride was scaled-up and further profiled. The synthetic protocols described in , were both suitable for a multi-gram scale synthesis of compound . An off-target screen was performed agains

• Much less is known about the and subunits

  2021-12-07

  

  Much less is known about the α3 and α4 subunits. GlyR α3 subunit immunoreactive synapses are concentrated in discrete bands across the IPL; besides, bipolar, amacrine and ganglion cells have been suggested to express it (Haverkamp et al., 2003, Wässle et al., 2009). In fact, All amacrine express α3

• br Recent insights into EAAT structure function aspects The

  2021-12-07

  

  Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen

• Volasertib There are two ways to transport FFAs into

  2021-12-07

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty Volasertib transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible

• br Role of BKCa in Cardiovascular System

  2021-12-07

  

  Role of BKCa in Cardiovascular System Perspective for BKCa Channels as Potential Target for Cardiovascular Diseases The intermediate conductance Ca-activated K+ channels (IKCa; KCa3.1, also known as SK4, IK, IKCa1, SMIK) were first discovered in erythrocytes by Gardos (1958) and then also fo

• In order t http www

  2021-12-07

  

  In order to validate the correctness of our interpretation of the gap-FRAP data and the analysis of GJC in astrocytes, we used a mathematical model based on morphological and experimental data. This mathematical model is based on SR101 diffusion in an elementary network. In agreement with the morpho

• At this point it needs however to be mentioned

  2021-12-06

  

  At this point it needs, however, to be mentioned that most in vivo studies regarding the herein discussed nuclear receptors were performed in rodents, especially in mice. Due to the significant differences in metabolism in mice and humans, not all results are translatable between these species and h

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