• br Results br Discussion Cell contact mediated

  2022-05-30

  

  Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi

• Currently ursodeoxycholic acid UDCA is the only recommended

  2022-05-30

  

  Currently, ursodeoxycholic aldehyde dehydrogenase (UDCA) is the only recommended and widely used drug in the treatment of CFLD. However, the clinical efficacy of UDCA is controversial. The most recent Cochrane review only identified a small number of trials assessing the effectiveness of UDCA [92].

• There is sufficient evidence to indicate that kisspeptin pla

  2022-05-30

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH 3146 receptor and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH was

• With taurine or other molecules

  2022-05-30

  

  With taurine, or other molecules that might be transported by Eaat2, an important area of research will be how such a chemical regulates sleep. Indeed, taurine has been described to act on the nervous system in disparate ways — it can act as an inhibitory neurotransmitter, but also has a well-charac

• In order to elucidate the reasons of

  2022-05-27

  

  In order to elucidate the reasons of high efficacy of , we evaluated the BOC group itself and the linkage between the BOC group and the benzene ring of A-part. Urea moiety (), the replacement of an oxygen ARRY-614 of the BOC group to a nitrogen atom, decreased the activity (EC = 0.12 μM), while the

• Herein in consider of the high similarity between

  2022-05-27

  

  Herein, in consider of the high similarity between GR HBP site and AR HBP site, we applied rational drug design strategy to develop AR/GR antagonists based on the chemical structures of antiandrogens and crystal structure of GR. The following bioassay identified Z19 as a dual AR/GR antagonist. Z19 i

• br Acknowledgements br Introduction Glucagon

  2022-05-27

  

  Acknowledgements Introduction Glucagon, a 29-amino E-4031 receptor peptide, is released from the pancreatic islets, intestine and stomach. Glucagon is released under hypoglycemic conditions and then elevates blood glucose levels, serving as a major counter hormone [1]. The regulation of gluco

• GOAT belongs to the super family of membrane

  2022-05-27

  

  GOAT belongs to the super family of membrane-bound O-acyltransferases (MBOATs). It is encoded by the gene MBOAT4 in human. The protein GOAT is highly conserved from zebrafish to human (Yanagi et al., 2018). GOAT is ubiquitously expressed with abundant expression in the stomach and intestine (Sakata

• For functional metagenomics based gene screening the DNA

  2022-05-27

  

  For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a

• br Materials and methods br

  2022-05-27

  

  Materials and methods Results Discussion FFAR4 is a G-protein coupled free fatty estrogen receptors receptor that has been reported to be expressed in osteoclasts and osteoblasts [18]. In this study the role of FFAR4 on the effects of different classes of UFAs, the ω−6 PUFA, AA, the ω−3 PUF

• Magtanong et al observed that caspase

  2022-05-27

  

  Magtanong et al. (2019) observed that caspase-dependent apoptotic lipotoxicity of saturated fatty acids is suppressed by exogenous MUFAs. This may explain the ability of MUFAs to prevent atherosclerosis, in contrast to the pathogenicity of saturated fatty acids. Moreover, MUFAs may promote while PUF

• br Discussion In response to an increase in glucose

  2022-05-27

  

  Discussion In response to an increase in glucose or DHA concentration, FBPase showed nuclear import and recruitment in a peripheral cell compartment. Interestingly, FBPase and GS were co-recruited to the periphery of the cells. This is precisely the site where glycogen is initially synthesized an

• Tyr phosphorylation of AnxA was first reported to be involve

  2022-05-27

  

  Tyr23 phosphorylation of AnxA2 was first reported to be involved in endocytosis, particularly in the internalisation of the insulin receptor [20]. Phosphorylated Tyr23 seems to be necessary for the stable association of AnxA2 with endosomes, and for their early-stage transport [14]. The role of AnxA

• One of the possibilities of HO targeting

  2022-05-27

  

  One of the possibilities of HO-1 targeting is gene therapy. So far, the majority of preclinical studies have focused on recombinant adeno-associated viral (rAAV) vectors as DNA carriers. They not only provide stable, long-term transgene expression in non-dividing dpp-4 inhibitor but also have very l

• Acknowledgement This work was supported

  2022-05-27

  

  Acknowledgement This work was supported by grants from the National Natural Science Foundation of China (No.81802749), Shenzhen Healthcare Research Project (No.SZBC2017029), the Science and Technology Foundation of Shenzhen (JCYJ20170412155231633, JSGG20170414104216477), National Key Research and D

14948 records 359/997 page Previous Next First page 上5页 356357358359360 下5页 Last page