• d Dimer may be the biomarker most strongly

  2018-11-14

  

  d-Dimer may be the biomarker most strongly associated with adverse events in HIV infection — from all-cause mortality in the SMART trial to venous thromboembolism and cardiovascular disease in prior published work (Kuller et al., 2008; Musselwhite et al., 2011; Nordell et al., 2014). Recent studies

• br Conclusions br Outstanding Questions br Search strategy a

  2018-11-14

  

  Conclusions Outstanding Questions Search strategy and Selection Criteria The following are the supplementary data related to this article. Authors\' Contributions Competing Interests Introduction Dendritic cells (DCs) are professional antigen presenting cells (APCs) that can effic

• The additive impact of progressive changes in sleep quality

  2018-11-14

  

  The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow, neurovascular and neurotransmitters, plus the cellular redox status are all likely to contribute to the cognitive deficits reported in up to one out of four newly diagnosed OSA patients (Rosenz

• Finally we advance some molecular

  2018-11-14

  

  Finally, we advance some molecular techniques such as host-pathogen RNA-seq, especially given the high GC content of Mtb, and the relative amounts of mammalian RNA to bacterial RNA: proverbial needles in a haystack. Host-pathogen RNA-seq has hitherto been discussed mainly as a theoretical possibilit

• This study has important limitations

  2018-11-14

  

  This study has important limitations. First, participants came from one academic medical center with its own patterns of clinic attendance, which may limit generalizability. The results may also differ by surgical specialty, which would be an interesting avenue for future investigation. Second, the

• According to HCV status we found a stronger association

  2018-11-14

  

  According to HCV status, we found a stronger association between low TGF-β1 concentrations and the risk of death from HCC among the HCV-positive group compared to the HCV-negative group, suggesting that the predictive value of TGF-β1 is more potent in higher risk HCV-positive individuals. This findi

• meclofenoxate Results br Discussion This Phase a

  2018-11-14

  

  Results Discussion This Phase 2a study of 32 patients is the largest ocular AAV clinical trial to date and serves to confirm the results of the Phase 1 study (Rakoczy et al., 2015), which showed that subretinal injection of rAAV.sFLT-1 is safe. The study also investigates the potential associati

• Since persistent telomeric DNA damage is a feature

  2018-11-14

  

  Since persistent telomeric DNA damage is a feature of replicative, stress- and oncogene-induced senescence, it has been suggested that unrepaired telomeres provide a source of persistent DDR signaling which is important to the establishment of senescence (Fumagalli et al., 2012). However, damage at

• The objective was to understand the diversity

  2018-11-14

  

  The objective was to understand the MRS 2578 Supplier of this organism across Europe and to get insight into the geographical and temporal evolution of the different genotypes. The diversity of P. jirovecii isolates responsible for PCP across different European countries (n=12) was investigated, i

• br Specifications table br Value of the data

  2018-11-14

  

  Specifications table Value of the data Data, experimental design, materials and methods C57BL/6 mice (sacrificed after 1, 3, 7, 10 and 14 days post-natal, n=3/age) were obtained from a colony at the Max Planck Institute for Molecular Genetics (Berlin, Germany) and left femora were dissected

• br Experimental design materials and methods

  2018-11-14

  

  Experimental design, materials and methods Acknowledgements This work was supported by the Sichuan Provincial Department of Education (Grant number 12ZB064 to Li Wang), the Scientific Research Foundation of Southwest Medical University (Grant number 2012QN-05 to Li Wang), and the Doctoral Scie

• br Data br Experimental design materials and methods

  2018-11-14

  

  Data Experimental design, materials and methods Acknowledgements Data Silk fibroin is a natural fibrous protein with advantages for protein loading and delivery in vitro and vivo. However, presumably because of the super-negative charge of fibroin, the application of intracellular delive

• Frontal and parietal activation have previously been associa

  2018-11-14

  

  Frontal and parietal activation have previously been associated with individual differences in spatial working memory performance in youth aged 9–18 (Klingberg et al., 2002; Olesen et al., 2007; Spencer-Smith et al., 2013). In our sample of 9–12 year olds, spatial working memory performance was not

• Ecological Momentary Assessment EMA is an

  2018-11-14

  

  Ecological Momentary Assessment (EMA) is an ecologically valid method for characterizing emotional reactivity and emotion regulation through repeated in vivo sampling. It entails the gathering of representative real-time data on emotion and behavior in natural environments through the use of signali

• br Amygdala involvement in social behavior throughout the li

  2018-11-13

  

  Amygdala involvement in social behavior throughout the lifespan In humans, the amygdala is implicated in social behavior in adults (Thomas et al., 2001), as well as during development (Skuse et al., 2003; Tottenham and Sheridan, 2009). Furthermore, research has shown that humans with disorders as

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